TFRC Mouse mAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss
货号：bsm-43165M
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概述
产品编号
bsm-43165M
英文名称
TFRC Mouse mAb
中文名称
转铁蛋白受体（CD71）单克隆抗体
英文别名
CD71; IMD46; T9; TFR; TFR1; TR; TRFR; p90; 2610028K12Rik; E430033M20Rik; Mtvr1; TFR1_HUMAN; TFRC; TFR1_MOUSE; TFR1_RAT;
抗体来源
Mouse
免疫原
Recombinant human CD71 protein: 89-760/760
亚型
IgG1
性状
Size : 50ul/100ul/200ul
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
5D12
理论分子量
85 kDa
检测分子量
90 kDa
浓度
1mg/ml
储存液
Size : 50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Cardiovascular > Blood > Serum Proteins
Immunology > Cell Type Markers > CD > Non-lineage
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Erythrocytic Lineage
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
转铁蛋白及转铁蛋白受体(TfnrR)是机体铁代谢中的重要因子，铁是细胞生长增殖、代谢的必需元素,转铁蛋白受体(TfR)介导的胞吞作用是细胞摄取铁的主要途径。肿瘤细胞因增殖生长旺盛,对铁的需求高,所以肿瘤细胞有比正常细胞更多的转铁蛋白受体的表达。
背景资料
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| Flow-Cyt | Human | 2ug/Test | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
TFRC
蛋白名
Transferrin receptor protein 1
亚基
Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.
亚细胞定位
Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
翻译后修饰
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
相似性
Belongs to the peptidase M28 family. M28B subfamily.
Contains 1 PA (protease associated) domain.
Contains 1 PA (protease associated) domain.
功能
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferring for an overlapping C-terminal binding site.
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