This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
Mouse
1:500-2000
交叉反应
交叉反应: Human (predicted: Mouse)
相关产品
暂无相关产品
靶标
基因名
TGOLN2
蛋白名
Trans-Golgi network integral membrane protein 2
亚细胞定位
Cell membrane. Golgi apparatus > trans-Golgi network membrane. Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.
组织特异性
Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
功能
May be involved in regulating membrane traffic to and from trans-Golgi network.