信号转导和转录激活因子6重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
信号转导和转录激活因子6重组兔单抗
货号:bsm-52239R
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概述

产品编号
bsm-52239R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
STAT6 Recombinant Rabbit mAb
中文名称
信号转导和转录激活因子6重组兔单抗
英文别名
D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C; STAT6_HUMAN; STAT6; IL-4 Stat; STAT6_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human STAT6: 800-847/847
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9A7
理论分子量
94 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
转录调节因子(Transcriptin Regulators)
背景资料
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Also known as: signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, MouseRat1:500-1000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
STAT6
蛋白名
Signal transducer and activator of transcription 6
亚基
Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
亚细胞定位
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
翻译后修饰
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
相似性
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.
功能
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

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