STING1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

Name: 跨膜蛋白173重组兔单抗（STING1 Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-60326R
Availability: InStock

Rrmab^?兔单抗

2026-07-01~2026-08-31，AB2607A 京东卡2026-07-01~2026-08-31，AB2607B 豪礼卡

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货号：bsm-60326R

产品详情

概述

产品编号

bsm-60326R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

STING1 Recombinant Rabbit mAb

中文名称

跨膜蛋白173重组兔单抗

英文别名

ERIS; MITA; MPYS; NET23; SAVI; STING; STING-beta; TMEM173; hMITA; hSTING; STING_HUMAN; STING1; Endoplasmic reticulum interferon stimulator (ERIS); Mediator of IRF3 activation (hMITA); Transmembrane protein 173; stimulator of interferon response cGAMP interactor 1; stimulator of interferon genes; endoplasmic reticulum IFN stimulator

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human STING: 250-379/379

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

H9B4

检测分子量

38 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Cancer > Signal transduction > Nuclear signaling > NFkB pathway

Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFkB pathway

Immunology > Immune System Diseases > Antiviral Signaling

Immunology > Innate Immunity > Cytokines > Interferons

Signal Transduction > Adapters > Transmembrane

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 340061 Human

SwissProt : Q86WV6 Human

产品介绍

STING由379个氨基酸构成，有数个跨膜结构域，在多种内皮细胞、上皮细胞中以及造血肝细胞均有表达。STING参与并促进DNA介导的先天免疫反应，即来自病毒和细菌的非CpG双链DNA与cGAS蛋白结合后被催化成第二信使cGAMP；接着二聚化的STING与cGAMP结合，发生构象变化，通过自噬小体（autophagsome）经内质网和高尔基体进一步进入细胞质，期间被泛素化后募集TBK1蛋白，再被磷酸化，之后与IRF3结合；接着IRF3被磷酸化后入核，诱导表达IFNs，细胞因子、T细胞募集因子等进而增强机体的免疫能力，更大限度的杀伤细菌，病毒等病原体。

背景资料

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

基因名

STING1

蛋白名

Stimulator of interferon genes protein

亚基

Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2.

亚细胞定位

Endoplasmic reticulum membrane. Mitochondrion outer membrane. Cell membrane. Cytoplasm > perinuclear region. In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.

组织特异性

Ubiquitously expressed.

翻译后修饰

Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity). Phosphorylated on Ser-358 by TBK1, leading to activation and production of IFN-beta.
Ubiquitinated. 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta. 'Lys-48'-linked polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation.

相似性

Belongs to the TMEM173 family.

功能

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.