This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009].
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat, Goat
1:2000-10000
交叉反应
交叉反应: Human, Mouse, Rat, Goat
相关产品
暂无相关产品
靶标
基因名
TF
蛋白名
Serotransferrin
亚基
Monomer.
亚细胞定位
Secreted.
组织特异性
Expressed by the liver and secreted in plasma.
疾病
Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.
相似性
Belongs to the transferrin family.
Contains 2 transferrin-like domains.
功能
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.