LAMP1 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,Flow-Cyt,ICC/IF,IF | Bioss

bs-1970R

LAMP1 Rabbit pAb

溶酶体相关膜蛋白1（CD107）抗体

CD107a; LAMPA; LGP120; LGP-120; LGP-A; Lamp-1; P2B; Perk; LAMP1_HUMAN; LAMP1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; LAMP1_MOUSE; 120 kDa lysosomal membrane glycoprotein; Lysosomal membrane glycoprotein A (LGP-A); LAMP1_RAT; 120 kDa lysosomal membrane glycoprotein (LGP-120);

Rabbit

KLH conjugated synthetic peptide derived from human LAMP-1: 301-417/417

IgG

Liquid

affinity purified by Protein A

Polyclonal

42 kDa

95 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD107a可很好的反映NK细胞活性，其表达水平的上调与NK分泌细胞因子的增多及NK对靶细胞的杀伤作用的增强高度相关，采用流式检测，CD107a还可鉴定出一群无细胞因子分泌的活性NK细胞。

Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.