CD43重组兔单抗
Rrmab®兔单抗
货号：bsm-60237R
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概述
产品编号
bsm-60237R
产品类型
重组兔单抗
英文名称
CD43 Recombinant Rabbit mAb
中文名称
CD43重组兔单抗
英文别名
CD43; GALGP; GPL115; LEU-22; LSN; A630014B01Rik; Ly-48; Ly48; LEUK_HUMAN; SPN; Galactoglycoprotein (GALGP); Leukocyte sialoglycoprotein; Sialophorin; LEUK_MOUSE; B-cell differentiation antigen LP-3; Lymphocyte antigen 48 (Ly-48);
抗体来源
Rabbit
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
H6G11
理论分子量
38 kDa
浓度
0.5mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Immunology > Cell Type Markers > CD > Non-lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Thrombocytic Lineage
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CD43又名白细胞唾液酸糖蛋白或唾液酸蛋白，是一种跨膜表面蛋白，在人体中有SPN（唾液蛋白）基因编码。CD43分子中的缺陷与Wiskott-Aldrich综合征的发病有关。
背景资料
This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:2000-10000 | |
| Flow-Cyt | Human | 1:50-100 |
交叉反应
交叉反应: Human
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靶标
基因名
SPN
蛋白名
Leukosialin
亚基
Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX.
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
翻译后修饰
Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
功能
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.
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