NR4A3 Rabbit pAb (一抗) | Bioss

2026-05-01~2026-06-30,AB2605
NR4A3 Rabbit pAb (一抗) | Bioss
货号:bs-11903R
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概述

产品编号
bs-11903R
产品类型
宠物抗体
英文名称
NR4A3 Rabbit pAb
中文名称
神经元衍生孤儿受体1抗体
英文别名
CHN; CSMF; MINOR; NOR1; NOR-1; TEC; NOR-2; NR4A3_HUMAN; NR4A3; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Translocated in extraskeletal chondrosarcoma; NR4A3_MOUSE; Orphan nuclear receptor TEC; NR4A3_RAT; Neuron-derived orphan receptor 1/2; Nuclear hormone receptor NOR-1/NOR-2; nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human NOR1: 521-626/626
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
68 kDa
检测分子量
68 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Nur77 (also designated NGFI-B), Nurr1 (Nur-related factor 1), and NOR-1 (neuron-derived orphan receptor 1) constitute the NGFI-B subfamily within the nuclear receptor superfamily. Ligands for these protein have not been identified, and, therefore, they are designated “orphan nuclear receptors”. Genes of the NGFI-B subfamily are classified as immediate-early genes, which are induced rapidly, but transiently, in response to a variety of stimuli. They have been implicated in cell proliferation, differentiation, and apoptosis. The human NOR-1 gene maps to chromosome 9q, and encodes a protein which is expressed in heart, skeletal muscle, thymus, and spleen as well as in brain, where it is developmentally regulated. There-fore, NOR-1 may be involved in regulating neural differentiation. The NOR-1 gene also undergoes chromosomal translocation with the EWS gene to produce a protein thought to affect pre-mRNA splicing.
神经元衍生孤儿受体1抗体-bs-11903R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouseHuman, Rat, Rabbit, Dog1:500-2000

交叉反应

交叉反应: Mouse (predicted: Human, Rat, Rabbit, Dog)

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靶标

基因名
NR4A3
蛋白名
Nuclear receptor subfamily 4 group A member 3
亚细胞定位
Nucleus.
组织特异性
Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
疾病
Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.
相似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
功能
Binds to the B1A response-element.

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