SMC2 Rabbit pAb (一抗) | Bioss
货号：bs-7727R
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概述
产品编号
bs-7727R
产品类型
农牧业/家禽抗体
英文名称
SMC2 Rabbit pAb
中文名称
染色体结构维持蛋白2抗体
英文别名
SMC2_HUMAN; SMC2; SMC protein 2; SMC-2; Chromosome-associated protein E (hCAP-E); XCAP-E homolog; CAPE; SMC2L1; CAP-E;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human SMC2: 401-500/1197
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
136 kDa
检测分子量
136 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Horse | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Horse)
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靶标
基因名
SMC2
蛋白名
Structural maintenance of chromosomes protein 2
亚基
Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
亚细胞定位
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
相似性
Belongs to the SMC family. SMC2 subfamily.
功能
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
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