The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have been shown to be almost identical to cJun in their C terminal regions, which are involved in dimerization and DNA binding, whereas their N terminal domains, which are involved in transcriptional activation, diverge. JunB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
Mouse
1:500-2000
IHC-P
Human, Mouse
1:50-200
IHC-F
Human, Mouse
1:50-200
IF
Human, Mouse
1:50-200
ICC/IF
Human
Mouse
1:50-200
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
JUNB
蛋白名
Transcription factor jun-B
亚基
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).
亚细胞定位
Nucleus.
翻译后修饰
Ubiquitinated by ITCH, leading to its degradation.
相似性
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
功能
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.