NUF2 Rabbit pAb (一抗) | Bioss
货号：bs-7714R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-7714R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
NUF2 Rabbit pAb
中文名称
细胞分裂周期相关蛋白1抗体
英文别名
CDCA1; CT106; NUF2R; NUF2_HUMAN; NUF2; hNuf2; hNuf2R; hsNuf2; Cell division cycle-associated protein 1; NUF2 component of NDC80 kinetochore complex; cell division cycle associated 1; NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); NDC80 kinetochore complex component NUF2; cancer/testis antigen 106
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human NUF2: 201-300/464
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
51 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IF | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1ug/Test |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Cow, Dog, Horse)
相关产品
暂无相关产品
靶标
基因名
NUF2
蛋白名
Kinetochore protein Nuf2
亚基
Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly interacts with CENPE; this interaction determines CENPE kinetochore localization.
亚细胞定位
Nucleus. Chromosome, centromere, kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
翻译后修饰
Can be phosphorylated by AURKA and AURKB.
相似性
Belongs to the NUF2 family.
功能
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-7714R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bs-7714R 被引用于4文献中