Jarid2 Rabbit pAb (一抗) | Bioss
货号：bs-11860R
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概述
产品编号
bs-11860R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Jarid2 Rabbit pAb
中文名称
组蛋白去甲基化酶JARID2抗体
英文别名
DIDDF; JMJ; jumonji; JARD2_HUMAN; JARID2; Jumonji/ARID domain-containing protein 2; JARD2_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Jarid2/Jumonji: 301-400/1246
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
139 kDa
检测分子量
139 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Pig, Sheep, Cow, Chicken, Dog, Horse)
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靶标
基因名
JARID2
蛋白名
Protein Jumonji
亚基
Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12.
亚细胞定位
Nucleus. Colocalizes with the PRC2 complex on chromatin.
组织特异性
During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
相似性
Contains 1 ARID domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
功能
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
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