CXCR3 Recombinant Rabbit mAb (一抗) - WB,ICC/IF | Bioss

Rrmab?兔单抗
2026-03-02~2026-04-30,KXJ2603
CXCR3 Recombinant Rabbit mAb (一抗) - WB,ICC/IF | Bioss
货号:bsm-54064R
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概述

产品编号
bsm-54064R
产品类型
重组兔单抗
英文名称
CXCR3 Recombinant Rabbit mAb
中文名称
细胞表面趋化因子受体3(CD183)重组兔单抗
英文别名
CXCR3_HUMAN; CXCR3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor (IP-10 receptor); GPR9;
抗体来源
Rabbit
免疫原
Recombinant human CXCR3 protein
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5F2
理论分子量
41 kDa
检测分子量
46 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
细胞表面趋化因子受体3(CD183)重组兔单抗-bsm-54064R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman1:500-2000
ICC/IFHuman1:100-500

交叉反应

交叉反应: Human

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靶标

基因名
CXCR3
蛋白名
C-X-C chemokine receptor type 3
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
翻译后修饰
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
N-glycosylated.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
Isoform 3 mediates the activity of CXCL11.

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