泛素蛋白连接酶重组兔单抗

bsm-54451R

重组兔单抗

Fbx32 Recombinant Rabbit mAb

泛素蛋白连接酶重组兔单抗

Fbx32; MAFbx; 4833442G10Rik; ATROGIN1; Gm20361; FBX32_BOVIN; FBXO32; FBX32_HUMAN; Atrogin-1; Muscle atrophy F-box protein (MAFbx); FBX32_MOUSE; FBX32_PIG; FBX32_RAT;

Rabbit

A synthesized peptide derived from human FBXO32: 20-84

IgG

Liquid

affinity purified by Protein A

Recombinant

2A3

42 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.