胚胎干细胞抑制蛋白Suz12重组兔单抗

bsm-52749R

重组兔单抗

SUZ12 Recombinant Rabbit mAb

胚胎干细胞抑制蛋白Suz12重组兔单抗

CHET9; IMMAS; JJAZ1; 2610028O16Rik; D11Ertd530e; mKIAA0160; SUZ12_HUMAN; SUZ12; Chromatin precipitated E2F target 9 protein (ChET 9 protein); Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog; KIAA0160; SUZ12_MOUSE;

Rabbit

A synthesized peptide derived from human SUZ12: 41-96

IgG

Liquid

affinity purified by Protein A

Recombinant

3C1

83 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

UZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. SUZ12 is a component of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.
SUZ12 is a component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2. SUZ12 mRNA is upregulated in a number of tumors including breast and colon.