肝肠钙粘连蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-60434R
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概述
产品编号
bsm-60434R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
CDH17／LI-cadherin Recombinant Rabbit mAb
中文名称
肝肠钙粘连蛋白重组兔单抗
英文别名
CDH16; HPT-1; HPT1; CAD17_HUMAN; CDH17; Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin (LI-cadherin);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Cadherin 17: 1-65/832
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
B5A7
理论分子量
90 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Cadherin家族，即钙离子依赖的细胞粘附素家族，是Takeichi最早发现的一种介导细胞间相互聚集的粘附分子，对生长发育过程中细胞的选择性聚集具有至关重要的作用。
背景资料
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CDH17
蛋白名
Cadherin-17
亚细胞定位
Cell membrane; Single-pass type I membrane protein (Potential).
组织特异性
Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.
Similarity : Contains 7 cadherin domains.
相似性
Contains 7 cadherin domains.
功能
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
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