CCBR1 Rabbit pAb (一抗) - WB | Bioss
货号：bs-6883R
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概述
产品编号
bs-6883R
产品类型
离子通道抗体
英文名称
CCBR1 Rabbit pAb
中文名称
钙离子通道阻端耐药蛋白CCBR1抗体
英文别名
XCT_HUMAN; SLC7A11; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT; CCBR1;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human xCT/CCBR1 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
55 kDa
检测分子量
57 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-1000 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
SLC7A11
蛋白名
Cystine/glutamate transporter
亚基
Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity).
亚细胞定位
Membrane; Multi-pass membrane protein.
相似性
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
功能
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
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