Histone H2B (mono methyl K5) Rabbit pAb (一抗) | Bioss

Name: 单甲基组蛋白H2B K5抗体（Histone H2B (mono methyl K5) Rabbit pAb）
Brand: 北京博奥森生物科技有限公司
SKU: bs-17427R
Availability: InStock

2026-03-02~2026-04-30，KXJ2603

一键复制说明书

货号：bs-17427R

产品详情

概述

产品编号

bs-17427R

产品类型

甲基化抗体、模式动物抗体、农牧业/家禽抗体

英文名称

Histone H2B (mono methyl K5) Rabbit pAb

中文名称

单甲基组蛋白H2B K5抗体

英文别名

H2BC4 | Histone H2B (mono-methyl-K5); H2BK5me1; me-Histone H2B; methyl-Histone H2B; me-H2B; H2BC4 | Histone H2B (mono-methyl-Lys5); GL105; H2B; H2B-GL105; H2B.1; H2BE; H2BFQ; H2BGL105; H2BQ; HIST2H2BE; H2B2E_HUMAN; H2BC21; H2B-clustered histone 21; Histone H2B-GL105; Histone H2B.q (H2B/q);

抗体来源

Rabbit

免疫原

KLH conjugated Synthesised methylpeptide derived from human Histone H2B around the methylation site of mono methyl Lys5: PA(mono methyl–K)SA

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Polyclonal

理论分子量

14 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies

Epigenetics and Nuclear Signaling > Histones > H2B > Acetylated

SWISS

Q16778

Gene ID

8349

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 8349 Human

Omim : 601831 Human

SwissProt : Q16778 Human

Unigene : 2178 Human

背景资料

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008]

产品应用

应用	预测种属	推荐稀释比例
WB	Human, Mouse, Rat, Cow, Chicken, Xenopus laevis	1:500-2000
IHC-P	Human, Mouse, Rat, Cow, Chicken, Xenopus laevis	1:100-500
IHC-F	Human, Mouse, Rat, Cow, Chicken, Xenopus laevis	1:100-500
IF	Human, Mouse, Rat, Cow, Chicken, Xenopus laevis	1:100-500
ICC/IF	Human, Mouse, Rat, Cow, Chicken, Xenopus laevis	1:100-500
ELISA	Human, Mouse, Rat, Cow, Chicken, Xenopus laevis	1:5000-10000

交叉反应

交叉反应: (predicted: Human, Mouse, Rat, Cow, Chicken, Xenopus laevis)

靶标

基因名

H2BC4

蛋白名

Histone H2B type 1-C/E/F/G/I

亚细胞定位

Nucleus. Chromosome.

翻译后修饰

Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.

相似性

Belongs to the histone H2B family.

功能

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Histone H2B (mono methyl K5) Rabbit pAb (一抗) | Bioss

概述

产品应用

交叉反应

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