CX3CR1 Rabbit pAb (一抗) | Bioss
货号：bs-1728R
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概述
产品编号
bs-1728R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
CX3CR1 Rabbit pAb
中文名称
趋化因子受体1抗体
英文别名
CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28; CX3C1_HUMAN; CX3CR1; C-X3-C CKR-1; Beta chemokine receptor-like 1 (CMK-BRL-1 | CMK-BRL1); Fractalkine receptor; G-protein coupled receptor 13; C-X3-C motif chemokine receptor 1; chemokine (C-X3-C) receptor 1; chemokine (C-X3-C motif) receptor 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CX3CR1: 151-250/355 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
39 kDa
检测分子量
47 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Invasion/microenvironment > ECM > Cell adhesion
Immunology > Immune System Diseases > Antiviral Signaling > HIV-related
Immunology > Innate Immunity > Chemokines > Delta Chemokine Receptors
Microbiology > Interspecies Interaction > Host Virus Interaction
Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
Neuroscience > Sensory System > Somatosensory system > Nociception
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human, Rabbit, Cow, Dog | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Rabbit, Cow, Dog | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Cow, Dog | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Cow, Dog | 1:100-500 |
| Flow-Cyt | Mouse | Human, Rat, Rabbit, Cow, Dog | 1ug/Test |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Cow, Dog)
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靶标
基因名
CX3CR1
蛋白名
CX3C chemokine receptor 1
亚基
Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Expressed in lymphoid and neural tissues.
疾病
Age-related macular degeneration 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
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