phospho-Cdc6 (Ser54) Rabbit pAb (一抗) | Bioss
货号：bs-5246R
产品详情
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概述
产品编号
bs-5246R
产品类型
磷酸化抗体、宠物抗体、农牧业/家禽抗体
英文名称
phospho-Cdc6 (Ser54) Rabbit pAb
中文名称
磷酸化细胞分裂周期蛋白6抗体
英文别名
Cdc6 (phospho-S54); p-Cdc6; phospho-Cdc6; Cdc6 (phospho-Ser54); CDC18L; HsCDC18; HsCDC6; MGORS5; p62(cdc6); CDC6_HUMAN; CDC6; CDC6-related protein; Cdc18-related protein (HsCdc18); p62(cdc6) (HsCDC6); CDC6_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human Cdc6 around the phosphorylation site of Ser54: PL(p-S)PR
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
63 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
转录调节因子（Transcriptin Regulators）
细胞分裂周期蛋白6也是细胞周期调节蛋白，是真核生物DNA复制的主要调控因子,参与构成DNA前复制复合物。
细胞分裂周期蛋白6也是细胞周期调节蛋白，是真核生物DNA复制的主要调控因子,参与构成DNA前复制复合物。
背景资料
Cell cycle events are regulated by the sequential activation and deactivation of cyclin depended kinase (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae). Cdc6 is also involved in checkpoint controls that ensure that DNA replication is completed before initiation of mitosis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Sheep, Dog, Horse | 1:50-200 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Pig, Sheep, Dog, Horse)
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靶标
基因名
CDC6
蛋白名
Cell division control protein 6 homolog
亚基
Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1.
亚细胞定位
Nucleus. Cytoplasm. The protein is nuclear in G1 and cytoplasmic in S-phase cells.
疾病
Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:613805]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
相似性
Sequence similaritiesBelongs to the CDC6/cdc18 family.
功能
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
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