Aconitase 1 Rabbit pAb (一抗) | Bioss

bs-9848R

农牧业/家禽抗体

Aconitase 1 Rabbit pAb

铁调节蛋白1抗体

ACOHC_HUMAN; ACO1; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1 (IRP1); Iron-responsive element-binding protein 1 (IRE-BP 1); 4.2.1.3; IREB1; ACOHC_MOUSE; Irebp; ACOHC_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human Aconitase 1/IRP-1: 101-200/889

IgG

Liquid

affinity purified by Protein A

Polyclonal

98 kDa

98 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.