alpha-Tubulin Rabbit pAb, Loading Control (一抗) | Bioss
货号：bs-0159R
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概述
产品编号
bs-0159R
产品类型
内参抗体、胞质（包浆或全细胞）内参抗体、农牧业/家禽抗体
英文名称
alpha-Tubulin Rabbit pAb, Loading Control
中文名称
微管蛋白α/Tubulin α（内参）抗体
英文别名
B-ALPHA-1; LIS3; TUBA3; Tuba-1; Tuba1; TBA1A_HUMAN; TUBA1A; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain; 3.6.5.-; TBA1A_MOUSE; Alpha-tubulin 1; Alpha-tubulin isotype M-alpha-1; Tubulin alpha-1 chain; TBA1A_RAT; tubulin alpha 1a; tubulin, alpha, brain-specific
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Tubulin-alpha 1: 375-448/451
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
50 kDa
检测分子量
52 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
结构蛋白（Structural Proteins）
tubulin是一种大量存在于哺乳动物脑组织中的微管亚基蛋白，在结构上是由两个极为相近的α和β亚基组成的二聚体、多聚体形成微管细丝，是微管的主要成分。
微管蛋白是球形分子, 有两种类型:α微管蛋白(α-tubulin)和β微管蛋白(β-tubulin)货号：bs-0210R, 这两种微管蛋白具有相似的三维结构, 能够紧密地结合成二聚体, 作为微管组装的亚基。
α亚基由450个氨基酸组成, β亚基是由455个氨基酸组成, 这两种亚基有35～40%的氨基酸序列同源, 表明编码它们的基因可能是由同一原始祖先演变而来.
tubulin是一种大量存在于哺乳动物脑组织中的微管亚基蛋白，在结构上是由两个极为相近的α和β亚基组成的二聚体、多聚体形成微管细丝，是微管的主要成分。
微管蛋白是球形分子, 有两种类型:α微管蛋白(α-tubulin)和β微管蛋白(β-tubulin)货号：bs-0210R, 这两种微管蛋白具有相似的三维结构, 能够紧密地结合成二聚体, 作为微管组装的亚基。
α亚基由450个氨基酸组成, β亚基是由455个氨基酸组成, 这两种亚基有35～40%的氨基酸序列同源, 表明编码它们的基因可能是由同一原始祖先演变而来.
背景资料
bs-0159P is one synthetic peptide derived from human Tubulin-alpha 1.
Tubulin is a major cytoskeleton that has five distinct forms, designated alpha, beta, gamma, delta and epsilon tubulin. The alpha and beta tubulins form a heterodimer that polymerize into the cylindrical microtubule fibers. Both alpha and beta tubulin bind GTP. Only beta tubulin hydrolyzes GTP to GDP. This hydrolysis is a process that is linked to tubulin polymerization and microtubule formation. The alpha tubulin isomer can be modified by addition of a C-terminal tyrosine residue. This modification may influence polymerization rates. The gamma tubulin isomer is localized to centrosomes which compose the heart of the microtubule organizing center from which microtubule fibers emanate.
Tubulin is a major cytoskeleton that has five distinct forms, designated alpha, beta, gamma, delta and epsilon tubulin. The alpha and beta tubulins form a heterodimer that polymerize into the cylindrical microtubule fibers. Both alpha and beta tubulin bind GTP. Only beta tubulin hydrolyzes GTP to GDP. This hydrolysis is a process that is linked to tubulin polymerization and microtubule formation. The alpha tubulin isomer can be modified by addition of a C-terminal tyrosine residue. This modification may influence polymerization rates. The gamma tubulin isomer is localized to centrosomes which compose the heart of the microtubule organizing center from which microtubule fibers emanate.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat, Sheep, Cow | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | Sheep, Cow | 1:100-500 |
| IHC-F | Human, Mouse, Rat | Sheep, Cow | 1:100-500 |
| IF | Human, Mouse, Rat | Sheep, Cow | 1:100-500 |
| Flow-Cyt | Rat | Human, Mouse, Sheep, Cow | 1μg/Test |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Sheep, Cow)
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靶标
基因名
TUBA1A
蛋白名
Tubulin alpha-1A chain
亚基
Dimer of alpha and beta chains.
亚细胞定位
Cytoplasm, cytoskeleton.
组织特异性
Ubiquitously expressed with highest levels in Brain, Bone, Adipocyte, and Breast
翻译后修饰
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
相似性
Belongs to the tubulin family.
功能
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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具体参考文献:bs-0159R 被引用于17文献中