CD44 Mouse mAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
流式诊断
货号：bsm-30038M
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常见问题
概述
产品编号
bsm-30038M
产品类型
病理级抗体、流式抗体、IVD-FC抗体
英文名称
CD44 Mouse mAb
中文名称
小鼠抗人CD44单克隆抗体
英文别名
CD44A; METAA; RHAMM; CD44_BOVIN; CD44; Extracellular matrix receptor III (ECMR-III); GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1 (PGP-1); Phagocytic glycoprotein I (PGP-I); CD44_HUMAN; CDw44; Epican; Heparan sulfate proteoglycan; LHR; MDU2; MDU3; MIC4; CD44_MOUSE; Lymphocyte antigen 24 (Ly-24); Ly-24; CD44_RAT;
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human CD44
亚型
Mouse IgG2a, k
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
4F6
理论分子量
85 kDa
检测分子量
80-95 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Tumor immunology > CD markers
Immunology > Cell Type Markers > CD > Adhesion
Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > CD markers ELISA kits
Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Dendritic Cell Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CD44是一个重要的细胞表面粘附分子。它在许多类型的人类细胞上都表达，在很多生理和病理过程中有复杂的作用，例如细胞迁移和在肿瘤细胞的生长调控中。CD44传递着诸多的细胞通路，有研究者认为CD44是一个新的信号通路蛋白。CD44介导淋巴细胞与血管内皮细胞包括粘膜组织中高内皮小静脉的粘连，这可能是通过激活其它粘附分子而间接造成的。CD44也是肿瘤细胞浸润的重要因素。
背景资料
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 | |
| Flow-Cyt | Human | 1ug/Test | |
| ICC/IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
相关产品
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靶标
基因名
CD44
蛋白名
CD44 antigen
亚基
Interacts with PKN2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.
亚细胞定位
Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.
组织特异性
Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
翻译后修饰
Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
相似性
Contains 1 Link domain.
功能
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
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