甘氨酰胺核苷酸合成酶重组兔单抗

bsm-52537R

重组兔单抗

GART Recombinant Rabbit mAb

甘氨酰胺核苷酸合成酶重组兔单抗

AIRS; GARS; GARTF; PAIS; PGFT; PRGS; Gaps; PUR2_HUMAN; GART; PUR2_MOUSE;

Rabbit

Recombinant Human GART protein: 570-750/1010

IgG

Liquid

affinity purified by Protein A

Recombinant

6A8

107 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Purines are critical for energy metabolism, cell signaling and cell reproduction and also function as precursors for coenzymes, energy transfer molecules, regulatory factors and proteins involved in RNA and DNA synthesis. GART (GAR transformylase), also referred to as AIRS, GARS, PAIS, PGFT, PRGS or GARTF, is 1,010 amino acids in length and is a key folate-dependent trifunctional enzyme with phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase and AICAR (phosphoribosylaminoimidazole synthetase) activity required for de novo purine biosynthesis. Cancer cells require considerable amounts of purines to sustain their accelerated growth and GART is, therefore, a target for cancer chemotherapy. GART is highly conserved in vertebrates. Two isoforms of GART are expressed due to alternative splicing events.