AGR2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss

bsm-52594R

重组兔单抗、mIHC精品抗体

AGR2 Recombinant Rabbit mAb

前梯度同源蛋白2重组兔单抗

AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8; PDIA17; RIFTD; XAG-2; Agr2h; mAG-2; AGR2_HUMAN; AGR2; Secreted cement gland protein XAG-2 homolog; AGR2_MOUSE; Protein Gob-4; Gob4; anterior gradient 2, protein disulphide isomerase family member; anterior gradient 2 homolog (Xenopus laevis); protein disulfide isomerase family A, member 17

Rabbit

A synthesized peptide derived from human AGR2: 1-64

IgG

Liquid

affinity purified by Protein A

Recombinant

3F8

20 kDa

18 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

AGR2 is a member of the anterior gradient homolog family. It is the human ortholog of XAG-2, the secreted Xenopus laevis Anterior Gradient protein. In X. laevis, it is involved in cement gland differentiation and neural marker gene expression. AGR2 is a secretory protein encoded by two different AGR2 transcripts. It interacts with LYPD3 and ?dystroglycan (DAG-1). AGR2 is ubiquitously expressed with up-regulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR). AGR2 may serve as a potential therapeutic marker for various cancers.

AGR2

Anterior gradient protein 2 homolog

Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.

Secreted. Endoplasmic reticulum.

Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.

Belongs to the AGR family.

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.