CENPC1 Recombinant Rabbit mAb (一抗) - WB,ICC/IF | Bioss

bsm-54360R

重组兔单抗

CENPC1 Recombinant Rabbit mAb

着丝粒蛋白C1重组兔单抗

CENP-C; CENPC1; MIF2; hcp-4; CENPC_HUMAN; CENPC; Centromere autoantigen C; Centromere protein C 1 (CENP-C 1); Interphase centromere complex protein 7; ICEN7; centromere protein C; centromere protein C 1

Rabbit

A synthesized peptide derived from human CENPC: 400-530

IgG

Liquid

affinity purified by Protein A

Recombinant

3A7

107 kDa

107 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.

CENPC

Centromere protein C

Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA.

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.

Belongs to the CENPC family.

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.