phospho-PDCD4 (Ser67) Rabbit pAb (一抗) | Bioss
货号：bs-12594R
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概述
产品编号
bs-12594R
产品类型
磷酸化抗体、宠物抗体、农牧业/家禽抗体
英文名称
phospho-PDCD4 (Ser67) Rabbit pAb
中文名称
磷酸化凋亡相关蛋白4抗体
英文别名
PDCD4 (phospho-S67); p-PDCD4; phospho-PDCD4; PDCD4 (phospho-Ser67); H731; D19Ucla1; Ma3; Tis; Dug; PDCD4_HUMAN; PDCD4; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a; PDCD4_MOUSE; Protein MA-3; Topoisomerase-inhibitor suppressed protein; PDCD4_RAT; Death up-regulated gene protein;
抗体来源
Rabbit
免疫原
KLH conjugated synthesised phosphopeptide derived from human PDCD4 around the phosphorylation site of Ser67: KN(p-S)SR
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
51 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
程序性细胞死亡因子4是近期发现一种新的抑癌基因，在很多肿瘤组织中有不同的表达。
背景资料
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 2ug/Test |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse)
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靶标
基因名
PDCD4
蛋白名
Programmed cell death protein 4
亚基
Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
亚细胞定位
Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
组织特异性
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
翻译后修饰
Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
相似性
Belongs to the PDCD4 family.
Contains 2 MI domains.
Contains 2 MI domains.
功能
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
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