This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human, Rat, Rabbit, Pig, Sheep, Cow, Horse
1:500-2000
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Sheep, Cow, Horse)
相关产品
暂无相关产品
靶标
基因名
CDH2
蛋白名
Cadherin-2
亚细胞定位
Cell membrane.
相似性
Contains 5 cadherin domains.
功能
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.