PHD2 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss
货号：bs-3686R
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概述
产品编号
bs-3686R
产品类型
农牧业/家禽抗体
英文名称
PHD2 Rabbit pAb
中文名称
脯氨酸羟化酶2抗体
英文别名
C1orf12; ECYT3; HALAH; HIF-PH2; HIFPH2; HPH-2; HPH2; PHD2; SM20; ZMYND6; EGLN1_HUMAN; EGLN1; Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2 | HIF-prolyl hydroxylase 2 | HPH-2); Prolyl hydroxylase domain-containing protein 2 (PHD2); SM-20; 1.14.11.29;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human PHD2: 42-140/426
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
47 kDa
检测分子量
43 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Cancer > Invasion/microenvironment > Hypoxia > Hydroxylases
Cardiovascular > Hypoxia > Prolyl Hydroxylase
Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > Prolyl hydroxylase
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Rabbit, Pig, Cow | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Rabbit, Pig, Cow | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Rabbit, Pig, Cow | 1:100-500 |
| IF | Human | Mouse, Rat, Rabbit, Pig, Cow | 1:100-500 |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Cow | 1:100-500 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Cow)
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靶标
基因名
EGLN1
蛋白名
Egl nine homolog 1
亚细胞定位
Cytoplasm. Nucleus.
组织特异性
According to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to PubMed:12788921; expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle.
相似性
Contains 1 Fe2OG dioxygenase domain.
Contains 1 MYND-type zinc finger.
Contains 1 MYND-type zinc finger.
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