Dopamine Transporter Rabbit pAb (一抗) | Bioss

2026-05-01~2026-06-30,AB2605
Dopamine Transporter Rabbit pAb (一抗) | Bioss
货号:bs-1714R
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概述

产品编号
bs-1714R
英文名称
Dopamine Transporter Rabbit pAb
中文名称
多巴胺转运蛋白DAT抗体
英文别名
DAT; DAT1; PKDYS; PKDYS1; SC6A3_HUMAN; SLC6A3; DA transporter; Solute carrier family 6 member 3; SC6A3_MOUSE; SC6A3_RAT; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; dopamine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 3; dopamine transporter; Sodium-dependent dopamine transporter
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human DAT1: 579-620/620 <Cytoplasmic>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
68 kDa
检测分子量
73 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
DATI 可能参与神经系统的多种活动,如学习记忆、嗅觉、感觉、运动、多巴胺神经递质活动的调节,而且可能参与胶质瘤等神经系统肿瘤的发生,阳性着色主要定位于细胞质,但也可见到有些细胞核内的阳性染色.
背景资料
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
多巴胺转运蛋白DAT抗体-bs-1714R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBRatHuman, Mouse1:500-2000

交叉反应

交叉反应: Rat (predicted: Human, Mouse)

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靶标

基因名
SLC6A3
蛋白名
Sodium-dependent dopamine transporter
亚基
Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1. Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2.
亚细胞定位
Membrane; Multi-pass membrane protein.
疾病
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.
相似性
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
功能
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

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