DATI 可能参与神经系统的多种活动,如学习记忆、嗅觉、感觉、运动、多巴胺神经递质活动的调节,而且可能参与胶质瘤等神经系统肿瘤的发生,阳性着色主要定位于细胞质,但也可见到有些细胞核内的阳性染色.
背景资料
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Rat
Human, Mouse
1:500-2000
交叉反应
交叉反应: Rat (predicted: Human, Mouse)
相关产品
暂无相关产品
靶标
基因名
SLC6A3
蛋白名
Sodium-dependent dopamine transporter
亚基
Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1. Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2.
亚细胞定位
Membrane; Multi-pass membrane protein.
疾病
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.
相似性
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
功能
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.