Fibronectin/FN1 Mouse mAb (一抗) - WB | Bioss
概述
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
Cancer > Invasion/microenvironment > ECM > Extracellular matrix
Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix
Developmental Biology > Lineage specification > Ectoderm
Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Fibronectin
Stem Cells > Lineage Markers > Ectoderm
细胞粘附蛋白（Call Adhesion Protein）
FaN（Fibronectin）是一种细胞粘附蛋白，参与细胞粘附，分化，移动，伤口愈合，凝血和机体防卫。主要分布于结缔组织及大部分基底膜上，作为判断良恶性上皮源性肿瘤(如乳腺癌等)的一个主要参考指标，亦可作为恶性肿瘤转移和病人预后的判断指标
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:1000-2000 |
交叉反应
交叉反应: Human
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靶标
It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
Phosphorylation sites are present in the extracellular medium.
Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.