平足蛋白/淋巴管内皮细胞蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-52936R
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概述
产品编号
bsm-52936R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Podoplanin Recombinant Rabbit mAb
中文名称
平足蛋白/淋巴管内皮细胞蛋白重组兔单抗
英文别名
AGGRUS; D2-40; GP36; GP40; Gp38; HT1A-1; OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A; E11; OTS-8; RANDAM-2; T1-alpha; T1alpha; RTI140; RTI40; PDPN_HUMAN; PDPN; Glycoprotein 36 (Gp36); PA2.26 antigen; T1-alpha (T1A); PDPN_MOUSE; Glycoprotein 38 (Gp38); Transmembrane glycoprotein E11 (E11); PDPN_RAT; E11 antigen epitope; Type I cell 40 kDa protein;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Podoplanin: 23-85
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3C3
理论分子量
15 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
Podoplanin Protein是一种肾小球足状突细胞膜粘蛋白，目前已成为一种新的淋巴管内皮标记物蛋白，在少数小静脉上也有表达。
podoplanin Protein是淋巴管内皮高度敏感且特异性的标记物，作为肿瘤细胞的血小板聚集介导因子而发挥作用，能促进肿瘤细胞迁移及增加肿瘤细胞侵袭力。
背景资料
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:1000-2000 | |
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
PDPN
蛋白名
Podoplanin
亚细胞定位
Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
组织特异性
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
翻译后修饰
Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
The N-terminus is blocked.
相似性
Belongs to the podoplanin family.
功能
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
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