Thrombopoietin Rabbit pAb (一抗) | Bioss

2026-03-02~2026-04-30,KXJ26032026-03-02~2026-04-30,促销赠品
Thrombopoietin Rabbit pAb (一抗) | Bioss
货号:bs-10407R
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概述

产品编号
bs-10407R
产品类型
农牧业/家禽抗体
英文名称
Thrombopoietin Rabbit pAb
中文名称
血小板生成素/巨核细胞集落刺激因子抗体
英文别名
TPO; MGDF; ML; CAMT2; MKCSF; MPLLG; THC9; THCYT1; Thpo; TPO_CANLF; C-MPL ligand (ML); Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor (MGDF); TPO_HUMAN; Myeloproliferative leukemia virus oncogene ligand; TPO_MOUSE; TPO_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Thrombopoietin: 21-120/353
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
37 kDa
检测分子量
35 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
血小板生成素/巨核细胞集落刺激因子抗体-bs-10407R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHumanMouse, Rat, Sheep, Cow1:500-2000

交叉反应

交叉反应: Human, Mouse, Rat (predicted: Sheep, Cow)

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靶标

基因名
THPO
蛋白名
Thrombopoietin
亚基
Interacts with DUOX1, DUOX2 and CYBA.
亚细胞定位
Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface.
疾病
Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the peroxidase family. XPO subfamily.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain.
功能
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

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