G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G-protein coupled receptors translate extracellular signals into intracellular signals (G-protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. P2RY8 (purinergic receptor P2Y, G-protein coupled, 8), also known as P2Y8, is a 359 amino acid multi-pass membrane protein that localizes to the cell membrane and belongs to the G protein-coupled receptor family. Expressed at low levels in lung, heart and kidney, P2RY8 may function as a receptor for purines that are coupled to G proteins and may also play a role in mental retardation.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:500-2000
Flow-Cyt
Human
2ug/Test
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
P2RY8
蛋白名
P2Y purinoceptor 8
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Probable receptor for purines coupled to G-proteins.