KRT18 | CK-18 Mouse mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

Name: 细胞角蛋白18单克隆抗体（KRT18 | CK-18 Mouse mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-33103M
Availability: InStock

2026-07-01~2026-08-31，AB2607B 豪礼卡

一键复制说明书文献引用(3)

货号：bsm-33103M

产品详情

概述

产品编号

bsm-33103M

产品类型

病理级抗体

英文名称

KRT18 | CK-18 Mouse mAb

中文名称

细胞角蛋白18单克隆抗体

英文别名

CK-18; CYK18; K18; CK18; Krt1-18; K1C18_HUMAN; KRT18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18 (CK-18); Keratin-18 (K18); K1C18_MOUSE; Cytokeratin endo B (Keratin D); Kerd; K1C18_RAT; keratin 18; keratin 18, type I

抗体来源

Mouse

免疫原

Recombinant human CK18 protein

亚型

IgG

性状

Size : 50ul/100ul/200ul
Liquid

Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.

纯化方法

affinity purified by Protein G

克隆类型

Monoclonal

克隆号

10H2

理论分子量

48 kDa

检测分子量

47 kDa

浓度

1mg/ml

储存液

Size : 50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS (pH7.4).

研究领域

Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class I > Cytokeratins

Tags & Cell Markers > Cell Type Markers > Tumor Associated

SWISS

P05783

Gene ID

3875

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 506480 Cow

Entrez Gene : 3875 Human

Entrez Gene : 16668 Mouse

Entrez Gene : 294853 Rat

Omim : 148070 Human

SwissProt : P05783 Human

SwissProt : P05784 Mouse

SwissProt : Q5BJY9 Rat

Unigene : 406013 Human

Unigene : 22479 Mouse

Unigene : 103924 Rat

产品介绍

结构蛋白（Structural Proteins）常用于肿瘤细胞的分化、增殖及转移方面的研究。

背景资料

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

基因名

KRT18

蛋白名

Keratin, type I cytoskeletal 18

亚基

Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.

亚细胞定位

Cytoplasm, perinuclear region. Nucleus, nucleolus.

组织特异性

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

翻译后修饰

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.
O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

疾病

Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600].

相似性

Belongs to the intermediate filament family.

功能

When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.