配对盒基因8重组兔单抗

bsm-52737R

重组兔单抗

PAX8 Recombinant Rabbit mAb

配对盒基因8重组兔单抗

PAX-8; PAX8_HUMAN; PAX8;

Rabbit

A synthesized peptide derived from human PAX8: 300-450/450

IgG

Liquid

affinity purified by Protein A

Recombinant

1A3

48 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

同源结构域蛋白（Homeodomain Proteins）
PAX8属于转录抑制因子PAXs的一种。在胚胎发育和肿瘤生长中起关键作用。其突变和某些肿瘤的发病有关。

This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.