MRP1/ABCC1 Rabbit pAb (一抗) | Bioss

bs-0657R

农牧业/家禽抗体、离子通道抗体

MRP1/ABCC1 Rabbit pAb

多药耐药相关蛋白1抗体

ABC29; ABCC; DFNA77; GS-X; MRP; MRP1; Abcc1a; Abcc1b; Mdrap; Avcc1a; MRP1_HUMAN; ABCC1; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter (LTC4 transporter); 7.6.2.2; MRP1_MOUSE; MRP1_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human MRP1: 501-600/1531 <Cytoplasmic>

IgG

Liquid

affinity purified by Protein A

Polyclonal

170 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多药耐药相关蛋白1(MRP1)是MRP家族中的一个成员之一，基因的染色体位点是16p13.1，它编码分子量是170-190kDa的MRP1蛋白。 MRP1又称ABCC1主要表达在消化系统中的肝脏、结肠和胰腺组织中，常用于多种肿瘤的多药耐药机制的研究。

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]