Haptoglobin beta Rabbit pAb (一抗) | Bioss

2026-03-02~2026-04-30,KXJ26032026-03-02~2026-04-30,促销赠品
Haptoglobin beta Rabbit pAb (一抗) | Bioss
货号:bs-9888R
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概述

产品编号
bs-9888R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Haptoglobin beta Rabbit pAb
中文名称
结合球蛋白β抗体
英文别名
BP; HP2ALPHA2; HPA1S; HP-1; preHP2; Ba1-647; HPT_HUMAN; HP; Zonulin; HPT_MOUSE; HPT_RAT; Liver regeneration-related protein LRRG173;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Haptoglobulin beta: 311-406/406
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
27/43 kDa
检测分子量
43 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
haptoglobin是一种酸性糖蛋白,属α2唾液酸糖蛋白,主要由肝脏合成,也可在脂肪细胞、皮肤、脾、肌肉、肺内等合成。
背景资料
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
结合球蛋白β抗体-bs-9888R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouseHuman, Rat, Cow, Dog, Horse1:500-2000

交叉反应

交叉反应: Mouse (predicted: Human, Rat, Cow, Dog, Horse)

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靶标

基因名
HP
蛋白名
Haptoglobin
亚基
Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163.
亚细胞定位
Secreted.
组织特异性
Expressed by the liver and secreted in plasma.
疾病
Anhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 2 Sushi (CCP/SCR) domains.
功能
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

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