phospho-SRF (Ser77) Rabbit pAb (一抗) | Bioss

2026-03-02~2026-04-30,KXJ26032026-03-02~2026-04-30,促销赠品
phospho-SRF (Ser77) Rabbit pAb (一抗) | Bioss
货号:bs-9602R
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概述

产品编号
bs-9602R
产品类型
磷酸化抗体、宠物抗体、农牧业/家禽抗体
英文名称
phospho-SRF (Ser77) Rabbit pAb
中文名称
磷酸化血清应答因子抗体
英文别名
STIP1 | SRF (phospho-S77); p-SRF; phospho-SRF; p-STIP1; STIP1 | SRF (phospho-Ser77); MCM1; SRF_HUMAN; SRF; SRF_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human SRF around the phosphorylation site of Ser77 : LY(p-S)GS
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
56 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
转录调节因子(Transcriptin Regulators)
血清应答因子(SRF)是一种转录因子蛋白,可以结合启动子DNA序列中的血清应答元件(SRE),调节一系列基因的表达,包括即刻早期基因的表达,如c-fos、fosB、junB、egr-1、egr-2,以及神经元基因nurr1、肌肉基因如肌动蛋白、肌球蛋白基因等.
背景资料
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].
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产品应用

应用已检合格种属预测种属推荐稀释比例
IHC-PHuman, Mouse, RatPig, Cow, Dog1:100-500
IHC-FHuman, Mouse, RatPig, Cow, Dog1:100-500
IFHuman, Mouse, RatPig, Cow, Dog1:100-500

交叉反应

交叉反应: Human, Mouse, Rat (predicted: Pig, Cow, Dog)

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靶标

基因名
STIP1
蛋白名
Stress-induced-phosphoprotein 1
亚基
Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI.
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by PRKDC.
相似性
Contains 1 MADS-box domain.
功能
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

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