This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Human, Mouse, Rat
Pig, Cow, Dog
1:100-500
IHC-F
Human, Mouse, Rat
Pig, Cow, Dog
1:100-500
IF
Human, Mouse, Rat
Pig, Cow, Dog
1:100-500
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Cow, Dog)
相关产品
暂无相关产品
靶标
基因名
STIP1
蛋白名
Stress-induced-phosphoprotein 1
亚基
Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI.
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by PRKDC.
相似性
Contains 1 MADS-box domain.
功能
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.