Phospholipase C beta 1 Rabbit pAb (一抗) | Bioss
货号：bs-6976R
产品详情
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常见问题
概述
产品编号
bs-6976R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Phospholipase C beta 1 Rabbit pAb
中文名称
磷酯酶Cβ1抗体
英文别名
DEE12; EIEE12; PI-PLC; PLC-154; PLC-I; PLC-beta-1; PLC154; PLCB1A; PLCB1B; 3110043I21Rik; Plcb; mKIAA0581; PLC'1; PLCbeta1; Phosphb; RATPHOSPHB; PLCB1_HUMAN; PLCB1; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I (PLC-I); Phospholipase C-beta-1 (PLC-beta-1); 3.1.4.11; KIAA0581; PLCB1_MOUSE; PLCB1_RAT; phospholipase C beta 1; phospholipase C, beta 1 (phosphoinositide-specific); phosphoinositide phospholipase C
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Phospholipase C beta 1: 441-540/1216
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
134 kDa
检测分子量
134 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Phospholipase C beta 1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Its gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for its gene.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Cow, Chicken, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1μg/Test |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Cow, Chicken, Dog, Horse)
相关产品
暂无相关产品
靶标
基因名
PLCB1
蛋白名
1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-1
亚基
Interacts with DGKQ.
亚细胞定位
Cytoplasmic and Nuclear.
疾病
Defects in PLCB1 are the cause of epileptic encephalopathy early infantile type 12 (EIEE12) [MIM:613722]. EIEE12 is a form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG.
相似性
Contains 1 C2 domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC Y-box domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC Y-box domain.
功能
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
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具体参考文献:bs-6976R 被引用于2文献中