phospho-FGFR1 (Tyr653 + Tyr654) Rabbit pAb (一抗) | Bioss
货号：bs-3205R
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概述
产品编号
bs-3205R
产品类型
磷酸化抗体、宠物抗体、农牧业/家禽抗体
英文名称
phospho-FGFR1 (Tyr653 + Tyr654) Rabbit pAb
中文名称
磷酸化碱性成纤维细胞生长因子受体1（CD331）抗体
英文别名
BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD; bFGF-R-1; Eask; FGFR-I; Fr1; Hspy; MFR; c-fgr; bFGF-R; FGFR1_HUMAN; FGFR1; Basic fibroblast growth factor receptor 1 (BFGFR | bFGF-R-1); Fms-like tyrosine kinase 2 (FLT-2); Proto-oncogene c-Fgr; 2.7.10.1; FGFR1_MOUSE; Basic fibroblast growth factor receptor 1; FGFR1_RAT; fibroblast growth factor receptor 1; fms-related tyrosine kinase 2; Pfeiffer syndrome; FGFR1 (phospho-Y653/Y654); p-FGFR1; phospho-FGFR1; FGFR1 (phospho-Tyr653/Tyr654)
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr653/654: ID(p-Y)(p-Y)KK <Cytoplasmic>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
88 kDa
检测分子量
135 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Growth factors > FGF
Cardiovascular > Angiogenesis > Growth Factors > FGF > FGF Receptors
Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
Neuroscience > Neurology process > Neurogenesis
Signal Transduction > Growth Factors/Hormones > FGF
Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
碱性成纤维细胞生长因子(bFGF)是一种多功能的生长因子,具有促进细胞有丝分裂和诱导新血管形成作用,和其受体(FGFR1)碱性成纤维细胞生长因子受体结合之后,在人体各组织中具有广泛的生物学活性和生理病理作用.越来越多的研究表明肿瘤细胞中bFGF-R1过度表达对肿瘤发生发展具有重要意义。
背景资料
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Rabbit, Pig, Cow, Dog, Horse | 1:500-2000 |
| IHC-P | Human, Rat | Mouse, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Human, Rat | Mouse, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IF | Human, Rat | Mouse, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Cow, Dog, Horse)
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靶标
基因名
FGFR1
蛋白名
Fibroblast growth factor receptor 1
亚基
Homodimer. Interacts with KLB. Interacts with KL and FGF23. Interacts with SHB and GRB10. Interacts with PLCG1 (via SH2 domains). Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2. Interacts with SOX2 and SOX3.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.
组织特异性
Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
翻译后修饰
Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
疾病
Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
功能
Receptor for fibroblast growth factors FGF2 and FGF1. Receptor for FGF23 in the presence of KL (By similarity). Promotes mitogenesis in response to fibroblast growth factors. Activates PLCG1.
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