phospho-PAK6 (Ser560) Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
货号：bs-3314R
产品详情
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常见问题
概述
产品编号
bs-3314R
产品类型
磷酸化抗体、宠物抗体、农牧业/家禽抗体
英文名称
phospho-PAK6 (Ser560) Rabbit pAb
中文名称
磷酸化p21激活激酶6抗体
英文别名
PAK5; PAK6_HUMAN; PAK6; PAK-5; p21-activated kinase 6 (PAK-6); 2.7.11.1; p21 (RAC1) activated kinase 6; p21(CDKN1A)-activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK6 (phospho-S560); p-PAK6; phospho-PAK6; PAK6 (phospho-Ser560)
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human PAK6 around the phosphorylation site of Ser560: RK(p-S)LV
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
75 kDa
检测分子量
73 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
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产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1ug/Test |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse)
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靶标
基因名
PAK6
蛋白名
Serine/threonine-protein kinase PAK 6
亚基
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.
亚细胞定位
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
组织特异性
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
翻译后修饰
Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
相似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CRIB domain.
Contains 1 CRIB domain.
功能
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
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