AKR7A2 Rabbit pAb (一抗) | Bioss
货号：bs-11706R
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概述
产品编号
bs-11706R
英文名称
AKR7A2 Rabbit pAb
中文名称
醛固酮类还原酶家族7成员A2抗体
英文别名
AFAR; AFAR1; AFB1-AR1; AKR7; 0610025K21Rik; Akr7a2; Aiar; ARK72_HUMAN; AFB1 aldehyde reductase 1 (AFB1-AR 1); Aldoketoreductase 7; Succinic semialdehyde reductase (SSA reductase); 1.1.1.n11; ARK72_MOUSE; Akr7a5; ARK72_RAT; rAFAR2; Afar2; aldo-keto reductase family 7 member A2; aflatoxin aldehyde reductase
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human AKR7A2: 81-150/359
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
40 kDa
检测分子量
37 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Metabolism > Pathways and Processes > Metabolic signaling pathways > Alcohol metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Types of disease > Cancer
Neuroscience > Neurology process > Neurodegenerative disease
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The aldo-keto reductase 7 (AKR7) family includes AKR7A2, AKR7A3 and AKR7A4 in human, AKR7A5 in mouse and AKR7A2 in rat, all of which function in the metabolism of aflatoxin B(1) and other dicarbonyl-containing compounds. More specifically, AKR7A proteins are involved in the metabolism of compounds with ketone groups on adjacent carbon atoms in a broad range of tissues, notably the liver. The human AKR7A2 gene maps to human chromosome 1p35-36, a region frequently deleted in sporadic colorectal cancer. The functional significance of this correlation lies in the constitutive expression of AKR7A2 in human liver to eliminate aflatoxin (an environmental carcinogen), thus acting as an endogenous chemo-preventative agent.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human, Rat)
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靶标
基因名
AKR7A2
蛋白名
Aflatoxin B1 aldehyde reductase member 2
亚基
Homodimer.
亚细胞定位
Golgi apparatus. Cytoplasm.
组织特异性
Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
相似性
Belongs to the aldo/keto reductase 2 family.
功能
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
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