Cryptochrome 1 Rabbit pAb (一抗) | Bioss

bs-11441R

宠物抗体、农牧业/家禽抗体

Cryptochrome 1 Rabbit pAb

隐花色素蛋白1抗体

DSPD; PHLL1; CRY1_HUMAN; CRY1; cryptochrome circadian regulator 1; cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1

Rabbit

KLH conjugated synthetic peptide derived from human Cryptochrome 1: 251-350/586

IgG

Liquid

affinity purified by Protein A

Polyclonal

64 kDa

70 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Circadian clocks are biological timepieces that regulate hormonal rhythms, sleep cycles and feeding behaviors. These rhythms are generated in the superchiasmatic nucleus (SCN), a cell-autonomous circadian oscillator located within the brain that is synchronized with the environment by light. A number of transcription factors, including Clock and BMAL1, are molecular components of the SCN that induce the expression of proteins involved in light/dark cycle entrainment, which include Per1 and Per2. Tim, for timeless, generates a negative feedback loop that regulates the activity of Clock by suppressing the expression of Clock target genes. Tim forms heterodimers with Per1 and Per2 that bind Clock and block the activation of Clock-BMAL1 dimers to repress Per gene expression. Additionally, the CRY proteins, which are cryptochrome photoreceptors for the circadian clock, function as light-independent inhibitors of the circadian clock. CRY1 and CRY2 negatively regulate SCN components by associating with the activators Clock-BMAL1, and also with the various feedback inhibitors Per1, Per2 and Tim.