紧密连接蛋白18重组兔单抗

bsm-60637R

重组兔单抗

Claudin 18.2 Recombinant Rabbit mAb

紧密连接蛋白18重组兔单抗

SFTA5; SFTPJ; CLD18_HUMAN; CLDN18; CLD18_MOUSE; D3ZLY1_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human Claudin-18.2

IgG

Liquid

affinity purified by Protein A

Recombinant

R7G12

28 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).