KDM6B Rabbit pAb (一抗) | Bioss

bs-20004R

农牧业/家禽抗体

KDM6B Rabbit pAb

组蛋白去甲基化酶JMJD3抗体

JMJD3; NEDCFSA; NEDSST; 1700064E03Rik; KDM6B_HUMAN; KDM6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B; 1.14.11.68; KIAA0346; KDM6B_MOUSE; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; lysine (K)-specific demethylase 6B

Rabbit

KLH conjugated synthetic peptide derived from human KDM6B: 1471-1570/1643

IgG

Liquid

affinity purified by Protein A

Polyclonal

177 kDa

177 kDa

1mg/ml

Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

JMJD3 is a 1,679 amino acid nuclear protein that contains one JmjC domain and belongs to the highly conserved JmjC domain-containing protein family. Functioning as a histone demethylase, JMJD3 uses iron and ascorbate as cofactors to demethylate dimethylated and trimethylated Lys-27 residues of Histone H3, thereby playing an important role in the modification of the histone code. Additionally, JMJD3 regulates posterior development and is involved in the inflammatory response, specifically by mediating macrophage differentiation. JMJD3 is also thought to control the expression of neurogenesis-related proteins and, via this regulatory mechanism, may be necessary for neural commitment during early development. Two isoforms of JMJD3 exist due to alternative splicing events.