Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epidermis (E-FABP, also designated psoriasis-associated FABP or PA-FABP), muscle and heart (H-FABP, also designated mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP), myelin (M-FABP) and testis (T-FABP). MDGI is highly expressed in the myocardium, skeletal and smooth muscle fibers, lipid and/or steroid synthesizing cells and terminally differentiated epithelia of the respiratory, intestinal and urogenital tracts.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:500-2000
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
FABP3
蛋白名
Fatty acid-binding protein, heart
亚细胞定位
Cytoplasm.
相似性
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
功能
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.