DUOX1 Rabbit pAb (一抗) - WB | Bioss
货号：bs-11431R
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概述
产品编号
bs-11431R
英文名称
DUOX1 Rabbit pAb
中文名称
双氧化酶1/甲状腺氧化酶1抗体
英文别名
LNOX1; NOXEF1; THOX1; 9930101G15Rik; Duox2; LNOX2; NOXEF2; P138-TOX; THOX2; DUOX1_HUMAN; DUOX1; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; Thyroid oxidase 1; 1.11.1.-; 1.6.3.1; DUOX; DUOX1_RAT; dual oxidase 1; flavoprotein NADPH oxidase; nicotinamide adenine dinucleotide phosphate oxidase
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human DUOX1: 1-100/1551 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
175 kDa
检测分子量
36 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
DUOX1
蛋白名
Dual oxidase 1
亚基
Interacts with TXNDC11, TPO and CYBA.
亚细胞定位
Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.
组织特异性
Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
翻译后修饰
N-glycosylated.
相似性
In the N-terminal section; belongs to the peroxidase family.
Contains 3 EF-hand domains.
Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.
Contains 3 EF-hand domains.
Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.
功能
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene).
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