缺氧诱导因子1β/HIF-1β重组兔单抗

bsm-52092R

重组兔单抗

HIF-1 beta Recombinant Rabbit mAb

缺氧诱导因子1β/HIF-1β重组兔单抗

ARNT_HUMAN; ARNT; ARNT protein; Class E basic helix-loop-helix protein 2 (bHLHe2); Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta (HIF-1-beta | HIF1-beta); BHLHE2; ARNT_MOUSE; ARNT_RAT;

Rabbit

A synthesized peptide derived from human HIF 1 beta: 450-789

IgG

Liquid

affinity purified by Protein A

Recombinant

3F5

87 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators）
低氧诱导因子1β不仅对于机体在缺氧条件下维持正常的生理功能具有特别重要的意义,并在肿瘤的生长以及神经细胞凋亡等病理过程中起重要作用. HIF1β又称芳烃受体核转运蛋白1能调节许多下游基因的表达水平.
哺乳动物细胞在低氧压力条件下出现HIF。HIF是一种转录因子，对细胞的缺氧起稳定作用。

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.