PDK1重组兔单抗

bsm-54037R

重组兔单抗

PDPK1 Recombinant Rabbit mAb

PDK1重组兔单抗

PDK1; PDPK2; PDPK2P; PRO0461; PDPK1_HUMAN; PDPK1; hPDK1; 2.7.11.1; PDPK1_MOUSE; mPDK1; PDPK1_RAT; Protein kinase B kinase (PkB kinase);

Rabbit

KLH conjugated synthetic peptide derived from human PDK1

IgG

Liquid

affinity purified by Protein A

Recombinant

2F9

61 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PDK1是蛋白激酶B(PKB)的上游激酶，通过与3,4,5三磷酸磷脂酰肌醇作用激活相邻的PKB分子。PDK1能够激活包含PKB在内的一系列的AGC激酶家族成员。从而调节细胞代谢，生长，扩散，生存，抗凋亡等诸多生理过程。

PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases.
PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.